Masafumi Arima, MD, PhD
Professor, Department of Rheumatology
Professional Information
Biography
Dr. Arima is a Professor in the Department of Rheumatology at Dokkyo Medical University School of Medicine in Mibu, Tochigi, Japan. He also serves as Faculty Member in the Integrated Research Faculty for Advanced Medical Sciences. His research focuses on transcriptional regulation in allergic immune responses, particularly the role of B-cell lymphoma 6 (Bcl6) in suppressing IL-4 production in memory CD4+ T cells, modulating TH2-mediated allergic inflammation. He explores cytokine and chemokine regulation in autoimmune and allergic diseases, and the roles of memory T and B cells in chronic inflammation. Dr. Arima has contributed to evaluating rush immunotherapy protocols for Hymenoptera venom allergy, enhancing understanding of efficacy and safety in severe insect venom allergy management.
Specialization
Immunology, Allergy, Rheumatology
Education
For elucidating the pathogenesis of refractory immune-mediated interstitial pneumonia and developing novel therapeutic strategies.; 2017: Dokkyo Medical Society Academic Encouragement Award; For demonstrating the attenuation of pulmonary fibrosis via exogenous S100A4 protein administration in murine models.; Selected Publications; “Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function”; PubMed.; Investigates the critical regulatory role of Bcl6 in TH2 immune responses, offering insights into IL-4 production control and allergic disease mechanisms.; “Efficacy and Safety of Rush Immunotherapy in Patients with Hymenoptera Allergy in Japan”; Published by researchers.dokkyomed.ac.jp.; Evaluates the clinical outcomes and safety of accelerated immunotherapy protocols in patients with Hymenoptera venom allergies in Japan.; Summary; Dr. Arima’s work bridges translational immunology, clinical rheumatology, and allergology, contributing to novel therapeutic approaches in autoimmune and allergic diseases, as well as innovations in immunotherapy protocols.
Research & Publications
- Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function. PubMed. Investigates the critical regulatory role of Bcl6 in TH2 immune responses, offering insights into IL-4 production control and allergic disease mechanisms. - Efficacy and Safety of Rush Immunotherapy in Patients with Hymenoptera Allergy in Japan. Published by researchers.dokkyomed.ac.jp. Evaluates the clinical outcomes and safety of accelerated immunotherapy protocols in patients with Hymenoptera venom allergies in Japan.