Ekaterina Rudnitsky, PhD

Biography

Dr. Ekaterina Rudnitsky is an active researcher at Ben-Gurion University of the Negev, where she contributes to cutting-edge studies on aging mechanisms, cellular senescence, and stem cell-based therapeutics. Her work focuses on the therapeutic applications of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs), particularly in mitigating age-related dysfunctions and enhancing longevity. Her research explores how stem-cell derived interventions can reprogram aging phenotypes, suppress senescence-associated pathways, and restore homeostatic functions in aged tissues. Selected Publications “Mesenchymal stem cells and their derivatives as potential longevity-promoting tools” Biogerontology, 2025; 26(3):96 This review outlines the role of MSCs and their EVs in promoting healthy aging, emphasizing their low immunogenicity, lack of tumorigenicity, and ability to rejuvenate omic profiles in aged animal models. (PubMed) “Stem cell-derived extracellular vesicles as senotherapeutics” Ageing Research Reviews, 2024; 99:102391 Explores stem cell-derived EVs as emerging tools in senotherapy, targeting cellular senescence through paracrine signaling and biomolecular modulation. (PubMed) “The Interplay between Cellular Senescence and Side Population Stem Cells” Aging Biology, 2025; 3:e20250039 Investigates the dynamic relationship between side population (SP) stem cells and cellular senescence, revealing insights into stem cell exhaustion and functional decline with aging. Conclusion Dr. Ekaterina Rudnitsky’s work represents a vital contribution to translational geroscience. Her studies on stem cell-based senotherapeutics provide promising avenues for aging intervention strategies, with potential implications for clinical applications in regenerative medicine and healthy lifespan extension.