Marcelo J Perone, PhD
Professor of Biochemistry
Professional Information
Biography
Prof. Marcelo Javier Perone is a leading voice in diabetes research, bridging molecular biology, immuno-endocrinology, and therapeutic innovation. He serves as Professor of Biochemistry at Universidad Austral, Argentina, as Researcher at CONICET (National Scientific and Technical Research Council), and as Principal Investigator of the Laboratory of Immuno-Endocrinology, Diabetes and Metabolism at the Institute for Translational Medicine Research (IIMT), Universidad Austral–CONICET. Prof. Perone specializes in the molecular mechanisms of type 1 and type 2 diabetes, with a particular focus on inflammatory cytokine effects on pancreatic beta cells, endoplasmic reticulum (ER) stress and oxidative stress, and beta cell survival, cytoprotective responses, and insulin secretion regulation. His goal is to identify novel therapeutic strategies for diabetes treatment by dissecting the cellular stress responses that lead to beta cell dysfunction. His work plays a pivotal role in advancing our understanding of beta cell biology and cellular stress responses, laying the groundwork for next-generation diabetes treatments.
Specialization
Diabetes
Education
Ph.D. in Biochemistry, Universidad Nacional de La Plata (1990–1995)
Postdoctoral Research:
- University of Manchester, United Kingdom
- University of Pittsburgh, USA (Thomas E. Starzl Transplantation Institute)
Research & Publications
"The role of SPARC protein in glucose homeostasis and insulin secretion" Demonstrated that SPARC deficiency negatively affects glucose metabolism and impairs insulin release. (PubMed) "Transplantation of marginal mass allogeneic islets co-encapsulated with 3D-cultured adult human skin-derived cells" Presented a novel strategy to improve glycemic control in diabetic mice. "Compound A reduces proinflammatory cytokine-induced endoplasmic reticulum stress in beta cells" Identified Compound A as a promising therapeutic candidate for reducing ER stress in beta cells. (CONICET)